Fetuin-A aggravates lipotoxicity in podocytes via interleukin-1 signaling
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چکیده
منابع مشابه
Fetuin‐A aggravates lipotoxicity in podocytes via interleukin‐1 signaling
Sterile inflammation is considered critical in the pathogenesis of diabetic nephropathy (DN). Here we show that Fetuin-A (FetA) or lipopolysaccharide (LPS) exacerbate palmitic acid-induced podocyte death, which is associated with a strong induction of monocyte chemoattractant protein-1 (MCP-1) and keratinocyte chemoattractant (KC). Moreover, blockage of TLR4 prevents MCP-1 and KC secretion and ...
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Received November 9, 2011; accepted August 17, 2012. From the Departments of Nutrition Sciences (L.H., T.K., Q.L., J.L., P.W., Y.Z., Q.Y., Y.D.) and Pharmacology (J.P.), University of Alabama at Birmingham, and Sanford-Burnham Medical Research Institute at Lake Nona, Orlando, FL (P.A.W.). The online-only Data Supplement is available with this article at http://circ.ahajournals.org/lookup/suppl/...
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ژورنال
عنوان ژورنال: Physiological Reports
سال: 2017
ISSN: 2051-817X
DOI: 10.14814/phy2.13287